Protective effect of oral administration of a traditional medicine, Juzen-taiho-to, and its components on lethal Candida albicans infection in immunosuppressed mice

被引：20

作者：

Abe, S

Tansho, S

Ishibashi, H

Inagaki, N

Komatsu, Y

Yamaguchi, H

机构：

[1] Teikyo Univ, Sch Med, Dept Microbiol & Immunol, Tokyo 1738605, Japan

[2] Tsumura & Co, Cent Res Labs, Kampo & Pharmacognosy Lab, Ibaraki, Osaka 3001155, Japan

[3] Teikyo Univ, Res Ctr Med Mycol, Tokyo 1920352, Japan

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1998年 / 20卷 / 03期

关键词：

D O I：

10.3109/08923979809034824

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protective effects of a kampo medicine, Juzen-taiho-to (TJ-48) and its herbal components against experimental candidiasis in cyclophosphamide-induced immunosuppressive mice were investigated. ICR mice were immunosuppressed by intraperitoneal treatment with cyclophosphamide (day-4) and were orally given TJ-48 or one of its 10 herbal components for 4 consecutive days (day-4 similar to-1). They were then challenged intravenously with a lethal dose of Candida albicans (day 0). An oral dose of 1g/kg/day of TJ-48 prolonged their life span. A similar protective effect was obtained by treatment with its component drugs-Ginseng radix, Glycyrrhizae radix, Atractylodis lancea rhizoma or Cnidii rhizoma. These herbal components were suggested to have a main role in the protective effect of Juzen-taiho-to against Candida infection.

引用

页码：421 / 431

页数：11

共 14 条

[1]

Abe S., 1997, Japanese Journal of Medical Mycology, V38, P223

[2]

Abe S., 1997, Japanese Journal of Medical Mycology, V38, P183

[3] Protection of C3H/HE J mice from development of Candida albicans infection by oral administration of Juzen-taiho-to and its component, ginseng radix: Possible roles of macrophages in the host defense mechanisms [J].