Pituitary volume in teenagers with first-presentation borderline personality disorder

被引：23

作者：

Garner, Belinda ^{[1
]}

Chanen, Andrew M. ^{[1
,2
]}

Phillips, Lisa ^{[3
]}

Velakoulis, Dennis ^{[4
]}

Wood, Stephen J. ^{[4
,5
]}

Jackson, Henry J. ^{[1
,3
]}

Pantelis, Christos ^{[4
]}

McGorry, Patrick D. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Dept Psychiat, ORYGEN Res Ctr, Melbourne, Vic, Australia

[2] NW Mental Hlth, ORYGEN Youth Hlth, Melbourne, Vic, Australia

[3] Univ Melbourne, Sch Behav Sci, Melbourne, Vic, Australia

[4] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia

[5] Austin & Repatriat Med Ctr, Brain Res Inst, Melbourne, Vic, Australia

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2007年 / 156卷 / 03期

基金：

英国医学研究理事会;

关键词：

MRI; HPA axis; childhood trauma;

D O I：

10.1016/j.pscychresns.2007.05.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study used magnetic resonance imaging to examine pituitary gland volume (PGV) in teenage patients with a first presentation of borderline personality disorder (BPD). No difference in PGV was observed between healthy controls (n=20) and the total BPD cohort (n=20). However, within the BPD cohort, those exposed to childhood trauma (n=9) tended to have smaller pituitaries (- 18%) than those with no history of childhood trauma (n = 10). These preliminary findings suggest that exposure to childhood trauma, rather than BPD, per se, might be associated with reduced PGV, possibly reflecting hypothalamic-pituitary-adrenal axis dysfunction. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：257 / 261

页数：5

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