Cloning and molecular analysis of the human citrate synthase gene

被引：17

作者：

Goldenthal, MJ ^{[1
]}

Marin-Garcia, J ^{[1
]}

Ananthakrishnan, R ^{[1
]}

机构：

[1] Mol Cardiol Inst, Highland Pk, NJ 08904 USA

来源：

GENOME | 1998年 / 41卷 / 05期

关键词：

human; citrate synthase; Krebs' cycle;

D O I：

10.1139/g98-074

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

The nucleotide sequence encoding the citrate synthase (CS) gene was determined from the sequencing of the CS cDNA isolated from a human heart cDNA library. The primary sequence of CS deduced from its nucleotide sequence reveals a highly conserved, albeit slightly larger, protein of 466 amino acids, with 95% homology to its pig homologue. The data also indicate that the human genomic CS gene contains no introns, and confirms the location of the human CS gene on chromosome 12.

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收藏

页码：733 / 738

页数：6

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