The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer

被引：555

作者：

Mabuchi, Seiji ^{[1
]}

Kuroda, Hiromasa ^{[1
]}

Takahashi, Ryoko ^{[1
]}

Sasano, Tomoyuki ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Obstet & Gynecol, Suita, Osaka 5650871, Japan

来源：

GYNECOLOGIC ONCOLOGY | 2015年 / 137卷 / 01期

关键词：

PI3K; AKT; mTOR; mTORC1; mTORC2; Ovarian cancer; CLEAR-CELL CARCINOMA; INHIBITION; MTOR; PIK3CA; PI3K; AKT; BREAST; GENE; PHOSPHORYLATION; ACTIVATION;

D O I：

10.1016/j.ygyno.2015.02.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway plays a critical role in the malignant transformation of human tumors and their subsequent growth, proliferation, and metastasis. Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is frequently activated in ovarian cancer, especially in clear cell carcinoma and endometrioid adenocarcinoma. Thus, this pathway is regarded as an attractive candidate for therapeutic interventions, and inhibitors targeting different components of this pathway are in various stages of clinical development. Here, we highlight the recent progress that has been made in our understanding of the PI3K/AKT/mTOR pathway and discuss the potential of therapeutic agents that target this pathway as treatments for ovarian cancer and the obstacles to their development. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：173 / 179

页数：7

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