The long-term response to levodopa in dopa-responsive dystonia

被引：56

作者：

Hwang, WJ ^{[1
]}

Calne, DB ^{[1
]}

Tsui, JKC ^{[1
]}

de la Fuente-Fernández, R ^{[1
]}

机构：

[1] Vancouver Hosp & Hlth Sci Ctr, Neurodegenerat Disorders Ctr, Vancouver, BC V5Z 1M9, Canada

来源：

PARKINSONISM & RELATED DISORDERS | 2001年 / 8卷 / 01期

关键词：

dopa-responsive dystonia; levodopa; dyskinesia; dopamine turnover;

D O I：

10.1016/S1353-8020(00)00084-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the long-term response to levodopa in 20 patients with dopa-responsive dystonia (DRD). We found an inverse correlation between the daily dose of levodopa and duration of treatment (r = -0.59, P < 0.01). Mild dyskinesias were present in 20% of our patients. Dyskinetic patients were on a higher dose of levodopa than non-dyskinetics. Dyskinesias responded to a reduction in levodopa, with no deterioration in motor function. We propose that the dopamine turnover might decrease with time, which would lead to a decrease in the requirement for levodopa and the occurrence of dyskinesias late in the course of DRD. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1 / 5

页数：5

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