Liquid-phase combinatorial synthesis: In search of small-molecule enzyme mimics

被引：28

作者：

Vandersteen, AM

Han, H

Janda, KD

机构：

[1] Scripps Res Inst, DEPT MOL BIOL, SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

[2] Scripps Res Inst, DEPT CHEM, SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

来源：

MOLECULAR DIVERSITY | 1996年 / 2卷 / 1-2期

关键词：

liquid-phase synthesis; poly(ethyleneglycol); enzyme mimic; combinatorial chemistry;

D O I：

10.1007/BF01718705

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The applications, advantages and recent advances in liquid-phase combinatorial chemistry using poly(ethyleneglycol) as a soluble polymer support are reviewed. Our recent efforts towards the synthesis of peptide-based catalysts on polyethyleneglycol are reported. The screening of libraries of peptides for catalysis is discussed.

引用

页码：89 / 96

页数：8

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