Sperm DNA damage assessment: a test whose time has come

被引：199

作者：

Agarwal, A

Allamaneni, SSR

机构：

[1] Cleveland Clin Fdn, Ctr Adv Res Human Reprod Infertil & Sexual Funct, Glickman Urol Inst, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Dept Obstet Gynecol, Cleveland, OH 44195 USA

来源：

FERTILITY AND STERILITY | 2005年 / 84卷 / 04期

关键词：

sperm DNA damage; male infertility; assisted reproduction; pregnancy;

D O I：

10.1016/j.fertnstert.2005.03.080

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Multiple techniques have been developed to measure the amount of sperm DNA damage in an effort to identify more objective parameters for evaluation of infertile men. We now have evidence to support that integrity of sperm DNA influences a couple's fertility and helps predict the chances of pregnancy and its successful outcome. The available tests of sperm DNA damage require additional large-scale clinical trials before their integration into routine clinical practice.

引用

页码：850 / 853

页数：4

共 16 条

[1]

Agarwal A, 2004, Minerva Ginecol, V56, P235

[2]

Role of reactive oxygen species in the pathophysiology of human reproduction [J].

Agarwal, A ;

Saleh, RA ;

Bedaiwy, MA .

FERTILITY AND STERILITY, 2003, 79 (04) :829-843

[3]

Role of sperm chromatin abnormalities and DNA damage in male infertility [J].

Agarwal, A ;

Said, TM .

HUMAN REPRODUCTION UPDATE, 2003, 9 (04) :331-345

[4]

Seeds of concern [J].

Aitken, RJ ;

Koopman, P ;

Lewis, SEM .

NATURE, 2004, 432 (7013) :48-52

[5]

Reply to:: sperm chromatin structural assay versus hypo-osmotic swelling test in predicting the need for in vitro fertilization with intracytoplasmic sperm injection [J].

Bungum, M .

HUMAN REPRODUCTION, 2005, 20 (03) :841-842

[6]

The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI [J].

Bungum, M ;

Humaidan, P ;

Spano, M ;

Jepson, K ;

Bungum, L ;

Giwercman, A .

HUMAN REPRODUCTION, 2004, 19 (06) :1401-1408

[7]

Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss [J].

Carrell, DT ;

Liu, L ;

Peterson, CM ;

Jones, KP ;

Hatasaka, HH ;

Erickson, L ;

Campbell, B .

ARCHIVES OF ANDROLOGY, 2003, 49 (01) :49-55

[8]

Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic [J].

Evenson, DP ;

Jost, LK ;

Marshall, D ;

Zinaman, MJ ;

Clegg, E ;

Purvis, K ;

de Angelis, P ;

Claussen, OP .

HUMAN REPRODUCTION, 1999, 14 (04) :1039-1049

[9]

Sperm chromatin structure assay: Its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques [J].

Evenson, DP ;

Larson, KL ;

Jost, LK .

JOURNAL OF ANDROLOGY, 2002, 23 (01) :25-43

[10]

Simple determination of human sperm DNA fragmentation with an improved sperm chromatin dispersion test [J].

Fernández, JL ;

Muriel, L ;

Goyanes, V ;

Segrelles, E ;

Gosálvez, J ;

Enciso, M ;

LaFromboise, M ;

De Jonge, C .

FERTILITY AND STERILITY, 2005, 84 (04) :833-842

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