Inflammasomes in health and disease

被引：1911

作者：

Strowig, Till ^{[1
]}

Henao-Mejia, Jorge ^{[1
]}

Elinav, Eran ^{[1
]}

Flavell, Richard ^{[1
,2
]}

机构：

[1] Yale Univ, Dept Immunobiol, New Haven, CT 06520 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

NATURE | 2012年 / 481卷 / 7381期

关键词：

SPECK-LIKE PROTEIN; INTERLEUKIN-1-BETA CONVERTING ENZYME; CASPASE RECRUITMENT DOMAIN; TYPE-2; DIABETES-MELLITUS; NF-KAPPA-B; NALP3; INFLAMMASOME; NLRP3; INSULIN-RESISTANCE; CELL-DEATH; INTESTINAL INFLAMMATION;

D O I：

10.1038/nature10759

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inflammasomes are a group of protein complexes built around several proteins, including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and damage signals by inflammasomes results in direct activation of caspase-1, which subsequently induces secretion of potent pro-inflammatory cytokines and a form of cell death called pyroptosis. Inflammasome-mediated processes are important during microbial infections and also in regulating both metabolic processes and mucosal immune responses. We review the functions of the different inflammasome complexes and discuss how aberrations in them are implicated in the pathogenesis of human diseases.

引用

页码：278 / 286

页数：9

共 100 条

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