Hypocretin/orexin-containing neurons are produced in one sharp peak in the developing ventral diencephalon

被引:26
作者
Amiot, C [1 ]
Brischoux, F [1 ]
Colard, C [1 ]
La Roche, A [1 ]
Fellmann, D [1 ]
Risold, PY [1 ]
机构
[1] Univ Franche Comte, Fac Med & Pharm, F-25041 Besancon, France
关键词
development; hypothalamus; melanin-concentrating hormone; rat;
D O I
10.1111/j.1460-9568.2005.04224.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The birth date of hypocretin-containing neurons was analysed using the bromodeoxyuridine method in the rat. The results indicate that these neurons are generated between embryonic days 11 (E11) and E14, with a sharp peak on E12. This spatiotemporal pattern of genesis contrasts with that of the co-distributed neurons producing the melanin-concentrating hormone in the lateral hypothalamic area, which have been described as generated in one large peak from E10 to E16. These observations may be linked to the relative distribution area of both populations.
引用
收藏
页码:531 / 534
页数:4
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