Signal transduction by a protease cascade

被引：94

作者：

LeMosy, EK

Hong, CC

Hashimoto, C

机构：

[1] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06520 USA

来源：

TRENDS IN CELL BIOLOGY | 1999年 / 9卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(98)01494-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.

引用

收藏

页码：102 / 107

页数：6

相关论文

共 36 条

[1] ESTABLISHMENT OF DORSAL-VENTRAL POLARITY IN THE DROSOPHILA EMBRYO - THE INDUCTION OF POLARITY BY THE TOLL GENE-PRODUCT [J].

ANDERSON, KV ;

BOKLA, L ;

NUSSLEINVOLHARD, C .

CELL, 1985, 42 (03) :791-798

[2] INTERACTION OF HEPARIN WITH PLASMINOGEN ACTIVATORS AND PLASMINOGEN - EFFECTS ON THE ACTIVATION OF PLASMINOGEN [J].

ANDRADEGORDON, P ;

STRICKLAND, S .

BIOCHEMISTRY, 1986, 25 (14) :4033-4040

[3] GLYCOSAMINOGLYCANS AND THE REGULATION OF BLOOD-COAGULATION [J].

BOURIN, MC ;

LINDAHL, U .

BIOCHEMICAL JOURNAL, 1993, 289 :313-330

[4]

CHASAN R, 1992, DEVELOPMENT, V115, P607

[5] THE ROLE OF EASTER, AN APPARENT SERINE PROTEASE, IN ORGANIZING THE DORSAL VENTRAL PATTERN OF THE DROSOPHILA EMBRYO [J].

CHASAN, R ;

ANDERSON, KV .

CELL, 1989, 56 (03) :391-400

[6] A GENE REQUIRED FOR THE SPECIFICATION OF DORSAL-VENTRAL PATTERN IN DROSOPHILA APPEARS TO ENCODE A SERINE PROTEASE [J].

DELOTTO, R ;

SPIERER, P .

NATURE, 1986, 323 (6090) :688-692

[7] Proteolytic processing of the Drosophila Spatzle protein by Easter generates a dimeric NGF-like molecule with ventralising activity [J].

DeLotto, Y ;

DeLotto, R .

MECHANISMS OF DEVELOPMENT, 1998, 72 (1-2) :141-148

[8] KINETIC-ANALYSIS OF THE EFFECTS OF GLYCOSAMINOGLYCANS AND LIPOPROTEINS ON UROKINASE-MEDIATED PLASMINOGEN ACTIVATION [J].

EDELBERG, JM ;

WEISSLER, M ;

PIZZO, SV .

BIOCHEMICAL JOURNAL, 1991, 276 :785-791

[9] THE MOLECULAR-BASIS OF BLOOD-COAGULATION [J].

FURIE, B ;

FURIE, BC .

CELL, 1988, 53 (04) :505-518

[10]

HASHIMOTO C, 1991, DEVELOPMENT, V111, P1021

← 1 2 3 4 →