Tuning swelling pH and permeability of hydrogel multilayer capsules

被引:53
作者
Kozlovskaya, Veronika [1 ]
Shamaev, Alexei [1 ]
Sukhishvili, Svetlana A. [1 ]
机构
[1] Stevens Inst Technol, Dept Chem & Chem Biol, Hoboken, NJ 07030 USA
关键词
D O I
10.1039/b719952j
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We report on tuning swelling pH transitions of hydrogel hollow capsules that were derived from hydrogen-bonded multilayers via chemical cross-linking. The capsules were either of a single component-a weak poly(carboxylic acid), such as poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(ethacrylic acid) (PEAA)-or contained two hydrogen-bonding polymers, such as in poly(carboxylic acid)/poly(N-vinylpyrrolidone-co-NH2) (PVPON-co-NH2) or in poly(carboxylic acid)/poly(N-vinylcaprolactam-co-NH2) (PVCL-co-NH2) systems. By varying the acidity of weak polyelectrolytes, the capsule swelling can be tuned over a wide pH range from 5 to 10. We show that differently from one-component capsules, the swelling amplitude of two-component capsules is limited by the number of cross-links provided by amino-containing units of a PVCL-co-NH2 copolymer. For two-component capsules with the same degree of cross-linking, permeability at the minimum swelling pH was decreased for PMAA-neutral copolymer capsules as compared to those of PAA-neutral copolymer. We also demonstrate that swelling pH of one-component capsules in the acidic region can be modulated via reversible association with a polycation. The fine control over the swelling pH transitions and permeability of hydrogel capsules enables their use in biomedical applications.
引用
收藏
页码:1499 / 1507
页数:9
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