Upregulation of hepcidin by interleukin-1β in human hepatoma cell lines

被引：36

作者：

Inamura, J ^{[1
]}

Ikuta, K ^{[1
]}

Jimbo, J ^{[1
]}

Shindo, M ^{[1
]}

Sato, K ^{[1
]}

Torimoto, Y ^{[1
]}

Kohgo, Y ^{[1
]}

机构：

[1] Asahikawa Med Coll, Dept Internal Med 3, Asahikawa, Hokkaido 0788510, Japan

来源：

HEPATOLOGY RESEARCH | 2005年 / 33卷 / 03期

关键词：

hepcidin; anemia of chronic disease (ACD); interleukin-1 beta (1L-1 beta); interleukin-6 (IL-6); iron metabolism; HuH-7; cells;

D O I：

10.1016/j.hepres.2005.08.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Anemia of chronic disease (ACD) is commonly observed in chronic inflammation, although its pathogenesis is poorly understood. Hepcidin is thought to be a key regulator in iron metabolism and has been implicated in AM Although the induction of hepcidin by an inflammatory cytokine interleukin-6 (IL-6) seems to have been confirmed, it is still controversial whether interleukin-1 beta (IL-1 beta), also known as an inflammatory cytokine, regulates hepcidin expression. We demonstrated that hepcidin mRNA was upregulated by IL-1 beta in human hepatoma-derived HuH-7 cells, particularly at low concentrations of IL-1 beta, while high concentrations of IL-6 were needed for the upregulation of hepcidin mRNA. Therefore, IL-1 beta might be more important for the upregulation of hepcidin in physiological conditions than IL-6. Although IL-1 beta induces IL-6 production in hepatocytes, our data indicate that the effect of IL-1 beta on hepcidin expression is independent from that of IL-6. In conclusion, IL-1 beta might have an important role in ACD. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：198 / 205

页数：8

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