Activation of muscarinic K+ current by β-adrenergic receptors in cultured atrial myocytes transfected with β1 subunit of heterotrimeric G proteins

被引：10

作者：

Bender, K ^{[1
]}

Wellner-Kienitz, MC ^{[1
]}

Meyer, T ^{[1
]}

Pott, L ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Inst Physiol, Abt Zellulare Physiol, D-44780 Bochum, Germany

来源：

FEBS LETTERS | 1998年 / 439卷 / 1-2期

关键词：

potassium channel; G protein; beta receptor; GIRK; cardiac cell;

D O I：

10.1016/S0014-5793(98)01350-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Muscarinic K+ channels (I-K(ACh)) in native atrial myocytes are activated by beta gamma subunits of pertussis toxin (Ptx)-sensitive heterotrimeric G proteins coupled to different receptors. beta gamma subunits of Ptx-insensitive G(s), coupled to beta-adrenergic receptors, do not activate native IK(ACh) In atrial myocytes from adult rats transfected with rat brain B-1 subunit IK(ach) can be activated by stimulation of beta-adrenergic receptors using isoprenaline. This effect is insensitive to Ptx. These findings demonstrate for the first time promiscuous (Ptx-insensitive) coupling of G(s beta gamma) to GIRK channels in their native environment. (C) 1998 Federation of European Biochemical Societies.

引用

页码：115 / 120

页数：6

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