A general and efficient strategy for 7-aryloctahydroindole and cis-3a-aryloctahydroindole alkaloids:: Total syntheses of (+/-)-γ-lycorane and (+/-)-crinane

被引：36

作者：

Gao, SH

Tu, YQ ^{[1
]}

Song, ZL

Wang, AX

Fan, XH

Jiang, YJ

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 16期

关键词：

D O I：

10.1021/jo0507690

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and efficient approach to both 7-aryloctahydroindole and cis-3a-aryloctahydroindole alkaloids has been developed. The key step involves Michael additions of the corresponding kinetics and thermodynamics lithium enolates of ketone 9 to the versatile building blocks: nitroethylene 10. Two representative members, (+/-)-gamma-lycorane and (+/-)crinane, have been synthesized in 22 and 36% overall yields, respectively.

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页码：6523 / 6525

页数：3

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