Dual therapy with statins and antioxidants is superior to statins alone in decreasing the risk of cardiovascular disease in a subgroup of middle-aged individuals with both diabetes mellitus and the haptoglobin 2-2 genotype

被引:21
作者
Blum, Shany [1 ]
Milman, Uzi [2 ,3 ]
Shapira, Chen [2 ,3 ]
Miller-Lotan, Rachel [1 ]
Bennett, Lawrence [2 ]
Kostenko, Maria [2 ,3 ]
Landau, Michele [5 ]
Keidar, Shlomo [4 ]
Levy, Yishai [4 ]
Khemlin, Alexander [2 ,3 ]
Radan, Arman [2 ,3 ]
Levy, Andrew P. [1 ]
机构
[1] Technion Israel Inst Technol, Techn Fac Med, IL-31096 Haifa, Israel
[2] Clalit Hlth Serv, Haifa, Israel
[3] Clalit Hlth Serv, Western Galilee, Israel
[4] Rambam Med Ctr, Haifa, Israel
[5] PharmaBrains Israel, Tel Aviv, Israel
关键词
D O I
10.1161/ATVBAHA.107.159905
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E18 / E20
页数:3
相关论文
共 24 条
[1]   Haptoglobin phenotypes differ in their ability to inhibit heme transfer from hemoglobin to LDL [J].
Bamm, VV ;
Tsemakhovich, VA ;
Shaklai, M ;
Shaklai, N .
BIOCHEMISTRY, 2004, 43 (13) :3899-3906
[2]  
BOWMAN BH, 1982, ADV HUM GENET, V12, P189
[3]   Is there any hope for vitamin E? [J].
Brown, BG ;
Crowley, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (11) :1387-1390
[4]   Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease [J].
Brown, BG ;
Zhao, XQ ;
Chait, A ;
Fisher, LD ;
Cheung, MC ;
Morse, JS ;
Dowdy, AA ;
Marino, EK ;
Bolson, EL ;
Alaupovic, P ;
Frohlich, J ;
Albers, JJ ;
Serafini, L ;
Huss-Frechette, E ;
Wang, S ;
DeAngelis, D ;
Dodek, A .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (22) :1583-1592
[5]   Antioxidant vitamins and lipid therapy - End of a long romance? [J].
Brown, BG ;
Cheung, MC ;
Lee, AC ;
Zhao, XQ ;
Chait, A .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (10) :1535-1546
[6]  
Ceriello Antonio, 2006, Endocr Pract, V12 Suppl 1, P60
[7]  
Collins R, 2002, LANCET, V360, P7, DOI 10.1016/S0140-6736(02)09327-3
[8]  
Langlois MR, 1996, CLIN CHEM, V42, P1589
[9]   Vitamin E in the primary prevention of cardiovascular disease and cancer - The Women's Health Study: A randomized controlled trial [J].
Lee, IM ;
Cook, NR ;
Gaziano, JM ;
Gordon, D ;
Ridker, PM ;
Manson, JE ;
Hennekens, CH ;
Buring, JE .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (01) :56-65
[10]   Application of pharmacogenomics in the prevention of diabetic cardiovascular disease: Mechanistic basis and clinical evidence for utilization of the haptoglobin genotype in determining benefit from antioxidant therapy [J].
Levy, Andrew P. .
PHARMACOLOGY & THERAPEUTICS, 2006, 112 (02) :501-512