Acid inhibition effect of ilaprazole on Helicobacter pylori-negative healthy volunteers: An open randomized cross-over study

被引：35

作者：

Du, Yi Qi ^{[1
]}

Guo, Wen Yuan ^{[3
]}

Zou, Duo Wu ^{[1
]}

Zhan, Xian Bao ^{[1
]}

Li, Zhen ^{[2
]}

Hu, Jin Hong ^{[2
]}

Gong, Yan Fang ^{[1
]}

He, Jia ^{[4
]}

Lu, Jian Ping ^{[1
]}

Li, Zhao Shen ^{[1
]}

机构：

[1] Second Mil Med Univ, Shanghai Changhai Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Shanghai Changhai Hosp, Dept Clin Pharmacol, Shanghai 200433, Peoples R China

[3] Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Gen Surg, Shanghai 200433, Peoples R China

[4] Second Mil Med Univ, Dept Hlth Stat, Shanghai 200433, Peoples R China

来源：

JOURNAL OF DIGESTIVE DISEASES | 2012年 / 13卷 / 02期

关键词：

ilaprazole; pharmacodynamics; proton pump inhibitor; PROTON PUMP INHIBITORS; GASTROESOPHAGEAL-REFLUX DISEASE; INTRAGASTRIC PH; OMEPRAZOLE; CYP2C19; ESOMEPRAZOLE; RABEPRAZOLE; PHARMACOKINETICS; LANSOPRAZOLE; ESOPHAGITIS;

D O I：

10.1111/j.1751-2980.2011.00557.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

OBJECTIVE: The aim of this study was to evaluate the effects and safety of different doses of ilaprazole on healthy volunteers without a Helicobacter pylori infection.

引用

页码：113 / 119

页数：7

共 21 条

[1]

Äbelö A, 2000, DRUG METAB DISPOS, V28, P966

[2]

Effect of CYP2C19 Genetic Polymorphism on Pharmacokinetics and Pharmacodynamics of a New Proton Pump Inhibitor, Ilaprazole [J].

Cho, Hoon ;

Choi, Min-Koo ;

Cho, Doo-Yeon ;

Yeo, Chang-Woo ;

Jeong, Hye-Eun ;

Shon, Ji-Hong ;

Lee, Jun-Yeoun ;

Shin, Jae-Soo ;

Cho, Mong ;

Kim, Dong-Yeon ;

Shin, Jae-Gook .

JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 52 (07) :976-984

[3]

Proton pump inhibitors - Do differences in pharmacokinetics translate into differences in clinical outcomes? [J].

Fock, Kwong Ming ;

Ang, Tiing Leong ;

Bee, Lean Choo ;

Lee, Edmund Jon Deon .

CLINICAL PHARMACOKINETICS, 2008, 47 (01) :1-6

[4]

CYP2C19 pharmacogenomics associated with therapy of Helicobacter pylori infection and gastro-esophageal reflux diseases with a proton pump inhibitor [J].

Furuta, Takahisa ;

Sugimoto, Mitsushige ;

Shirai, Naohito ;

Ishizaki, Takashi .

PHARMACOGENOMICS, 2007, 8 (09) :1199-1210

[5]

Monitoring cytochrome P-450 activity during rabeprazole treatment in patients with gastresophageal reflux disease [J].

Giannini, Edoardo G. ;

Savarino, Vincenzo ;

Testa, Roberto .

DIGESTIVE DISEASES AND SCIENCES, 2006, 51 (09) :1602-1606

[6]

Randomized, parallel, double-blind comparison of the ulcer-healing effects of ilaprazole and omeprazole in the treatment of gastric and duodenal ulcers [J].

Ho, Khek Yu ;

Kuan, Arlene ;

Zano, Felix ;

Goh, Khean Lee ;

Mahachai, Varocha ;

Kim, Dong Yeon ;

Yoon, Hwan Min .

JOURNAL OF GASTROENTEROLOGY, 2009, 44 (07) :697-707

[7]

Relation between oesophageal acid exposure and healing of oesophagitis with omeprazole in patients with severe reflux oesophagitis [J].

Holloway, RH ;

Dent, J ;

Narielvala, F ;

Mackinnon, AM .

GUT, 1996, 38 (05) :649-654

[8]

Effect of CYP2C19*2 and*17 mutations on pharmacodynamics and kinetics of proton pump inhibitors in Caucasians [J].

Hunfeld, Nicole G. ;

Mathot, Ron A. ;

Touw, Daan J. ;

van Schaik, Ron H. ;

Mulder, Paul G. ;

Franck, Paul F. ;

Kuipers, Ernst J. ;

Geus, William P. .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 65 (05) :752-760

[9]

Comparison of IY81149 with omeprazole in rat reflux oesophagitis [J].

Kil, BJ ;

Kim, IW ;

Shin, CY ;

Jeong, JH ;

Jun, CH ;

Lee, SM ;

Kim, DY ;

Huh, IH ;

Sohn, UD .

JOURNAL OF AUTONOMIC PHARMACOLOGY, 2000, 20 (5-6) :291-296

[10]

Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities [J].

Li, XQ ;

Andersson, TB ;

Ahlström, M ;

Weidolf, L .

DRUG METABOLISM AND DISPOSITION, 2004, 32 (08) :821-827

← 1 2 3 →