The structure of the human glutathione synthetase gene

被引：15

作者：

Whitbread, L ^{[1
]}

Gali, RR ^{[1
]}

Board, PG ^{[1
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Mol Genet Grp, Canberra, ACT 2601, Australia

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1998年 / 112卷

关键词：

glutathione; metabolism; glutathione synthetase gene;

D O I：

10.1016/S0009-2797(97)00149-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study we have isolated two overlapping cosmid clones which contain the sequence of the human glutathione synthetase gene. The size of the gene is approximate to 32 kb and it is composed of 13 exons with the intron sizes ranging from 102 bp to 6 kb. We have also shown an alignment of the amino acid sequences of all currently known eukaryotic glutathione synthetases. This alignment highlights conserved regions that may be of structural or functional significance. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：35 / 40

页数：6

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