Retrovirally mediated overexpression of peroxiredoxin VI increases the survival of WI-38 human diploid fibroblasts exposed to cytotoxic doses of tert-butylhydroperoxide and UVB

被引：33

作者：

Dierick, JF

Wenders, F

Chainiaux, F

Remacle, J

Fisher, AB

Toussaint, O

机构：

[1] Fac Univ Notre Dame Paix, Unit Res Cellular Biol, B-5000 Namur, Belgium

[2] Univ Penn, Med Ctr, Inst Environm Med, Philadelphia, PA 19104 USA

来源：

BIOGERONTOLOGY | 2003年 / 4卷 / 03期

关键词：

1-cys peroxiredoxin; antioxidant protein 2; cytotoxicity; ethanol; H2O2; oxidative stress; peroxiredoxin VI; tert-butylhydroperoxide; UVB;

D O I：

10.1023/A:1024154024602

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In this work, stable overexpression of peroxiredoxin VI was generated in WI-38 human diploid fibroblasts using a retrovirus-mediated transfection system. Estimation of cell survival showed that peroxiredoxin VI provides a significant protection against tert-butylhydroperoxide- or UVB-caused cytotoxicity. No protection was found against ethanol- or H2O2-caused cytotoxicity. These effects are correlated with the known functions of Prx VI.

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页码：125 / 131

页数：7

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