Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum

被引：36

作者：

Yang, N.-Y.

Qian, S.-H.

Duan, J.-A.

Li, P. ^{[1
]}

Tian, L.-J.

机构：

[1] China Pharmaceut Univ, Dept Pharmacognosy, Nanjing 210038, Peoples R China

[2] Jiangsu Acad Tradit Chinese Med, Dept Phytochem, Nanjing 210028, Peoples R China

[3] Jinling Pharmaceut Co Ltd, Ctr Technol, Nanjing 210009, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2007年 / 9卷 / 04期

关键词：

Eupatorium lindleyanum; compositae; sesquiterpene; eupalinolide C; eupalinolide D; eupalinolide E;

D O I：

10.1080/10286020600727673

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Three new germacrane sesquiterpenes, eupalinolides C -E (1-3), along with three known germacrane sesquiterpenes, eupalinolide A (4), eupalinolide B (5), and 3 beta-acetoxy-8 beta-(4'-hydroxytigloyloxy)-14hydroxycostunolide (6), were isolated from Eupatorium lindleyanum. They were tested for cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines. The results showed that these compounds demonstrated potent cytotoxicity. The structures of the compounds were elucidated by means of (1) H and (13) C NMR spectroscopic analysis, including 2D NMR experiments.

引用

页码：339 / 345

页数：7

共 7 条

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A HELIANGOLIDE FROM CHROMOLAENA-GLABERRIMA [J].