Advances in transcutaneous vaccine delivery: Do all ways lead to Rome?

被引：153

作者：

Bal, Suzanne M. ^{[1
]}

Ding, Zhi ^{[1
]}

van Riet, Elly ^{[2
]}

Jiskoot, Wim ^{[1
]}

Bouwstra, Joke A. ^{[1
]}

机构：

[1] Leiden Amsterdam Ctr Drug Res, Div Drug Delivery Technol, Leiden, Netherlands

[2] Natl Inst Infect Dis, Influenza Virus Res Ctr, Musashimurayama, Tokyo, Japan

来源：

JOURNAL OF CONTROLLED RELEASE | 2010年 / 148卷 / 03期

关键词：

Adjuvant; Microneedles; Skin immune system; Transcutaneous vaccine delivery; HEAT-LABILE ENTEROTOXIN; DENDRITIC CELL SUBSETS; TOLL-LIKE RECEPTORS; B SURFACE-ANTIGEN; EPIDERMAL POWDER IMMUNIZATION; CYTOTOXIC T-LYMPHOCYTES; HUMAN LANGERHANS CELLS; NECROSIS-FACTOR-ALPHA; HIV-1 DNA VACCINE; ESCHERICHIA-COLI;

D O I：

10.1016/j.jconrel.2010.09.018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transcutaneous immunization (TCI) is a promising alternative to vaccine delivery via the subcutaneous and intramuscular routes, due to the unique immunological characteristics of the skin. The increasing knowledge of the skin immune system and the novel delivery methods that have become available have boosted research on new vaccination strategies. However, TCI has not yet been exploited to its full potential, because the barrier function of the stratum corneum, the top layer of the skin, is difficult to overcome. In this review we first discuss the immune system of the skin, focusing on the role the different types of skin residing dendritic cells play in the immune response. Subsequently, adjuvants and the large variety of devices, in particular microneedles, developed to deliver vaccines into the skin are summarized. Clearly, many ways have been explored to achieve efficient transcutaneous vaccination with varying success. The perspectives of the most promising concepts will be discussed. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：266 / 282

页数：17

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