A prenylbisabolane with NF-κB inhibiting properties from Cascarilla (Croton eluteria)

被引：4

作者：

Campagnuolo, C

Fattorusso, E

Petrucci, F

Taglialatela-Scafati, O

Appendino, G

Marquez, N

Muñoz, E

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Piemonte Orientale, DISCAFF, I-28100 Novara, Italy

[3] Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba 14004, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 13期

关键词：

Cascarilla; diterpenoids; prenylbisabolane; NF-kappa B inhibition;

D O I：

10.1016/j.bmc.2005.04.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Investigation of the bark of Croton eluteria Bennett for biologically active compounds has led to the isolation of the new prenylbisabolane 3, whose structure was assessed by spectroscopic methods. The corresponding known enone 4 and the eudesmane sesquiterpene 2 were also obtained. Compound 3 proved active in selectively inhibiting the induction of NF-kappa B by tumor necrosis factor-alpha in T cells. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：4238 / 4242

页数：5

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