Human health risk assessment of organochlorines associated with fish consumption in a coastal city in China

被引:203
作者
Jiang, QT
Lee, TKM
Chen, K
Wong, HL
Zheng, JS
Giesy, JP
Lo, KKW
Yamashita, N
Lam, PKS
机构
[1] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
[2] Zhejiang Univ, Dept Epidemiol & Hlth Stat, Sch Med, Hangzhou 310031, Zhejiang Prov, Peoples R China
[3] Michigan State Univ, Dept Zool, Natl Food Safety & Toxicol Ctr, E Lansing, MI 48824 USA
[4] Natl Inst Adv Ind Sci & Technol, EMTECH, Tsukuba, Ibaraki, Japan
关键词
health risk assessment; organochlorines; dioxin-like compounds; diet consumption; coastal city;
D O I
10.1016/j.envpol.2004.09.028
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Food consumption is an important route of human exposure to organochlorines (OCs). In order to assess the potential health risks associated with these contaminants due to fish consumption, five species of fish were collected from a local market in Zhoushan City, an island in the East China Sea. Dioxin-like compounds, such as polychlorinated dibenzo-p-dioxins/ dibenzofurans, in the fish samples were screened by H4IIE-luc cell bioassay, and the concentrations of specific organochlorines were measured by gas chromatograph-electron capture detector (GC-ECD). The bioassay results indicated that concentrations of dioxin-like compounds in the fish samples were below detection limit (0.64 pg/mL). The concentrations of OC pesticides and PCBs ranged from 0.67 to 13 and 0.24 to 1.4 ng/g wet wt., respectively. Significantly, concentrations of pp'-DDE in fish meat were comparatively high (average 3.9 ng/g wet wt.) compared with the other OC pesticides. The daily fish consumption, based on a dietary survey conducted among 160 local healthy residents, was determined to be 105 g/person. The relevant cancer benchmark concentrations of HCB, dieldrin, chlordane, DDTs and PCBs were 0.36, 0.04, 1.6, 1.7, and 0.29 ng/kg per day, respectively, based on the local diet. The hazard ratios (HRs), based on non-cancer endpoints were all less than 1.0, while the HRs based on cancer were greater than 1.0 for certain contaminants based on the 95th centile concentration in fish tissue. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:155 / 165
页数:11
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