pH, EF-1 alpha and the cytoskeleton

One of the unexpected cellular components found interacting with the cytoskeleton is elongation factor 1 alpha (EF-1 alpha). How this interaction is regulated is not clear, but pH may be a potent regulator. Interestingly, pH also regulates the amount of protein translation occurring in many cell systems. In this paper, the authors suggest that sequestration of EF-1 alpha in the cytoskeleton may play a key role in regulating the spatial distribution of macromolecular assembly in a way that is dependent on cytoplasmic pH.