The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function

被引：167

作者：

Lanier, LL

Bakker, ABH

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Inst Canc Res, San Francisco, CA 94143 USA

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 12期

关键词：

D O I：

10.1016/S0167-5699(00)01745-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses.

引用

收藏

页码：611 / 614

页数：4

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