Evidence for gliotoxin-glutathione conjugate adducts

被引：15

作者：

Bernardo, PH

Chai, CLL ^{[1
]}

Deeble, GJ

Liu, XM

Waring, P

机构：

[1] Australian Natl Univ, The Faculties, Dept Chem, Canberra, ACT 0200, Australia

[2] Australian Natl Univ, John Curtin Sch Med Res, Div Cell Biol & Immunol, Canberra, ACT 0200, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/S0960-894X(00)00696-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200+/-100 M-1 at pH 7.0 at 25 degreesC. Under conditions where the reaction was quenched rapidly with the addition of acid: gliotoxin-glutathione conjugate adducts were detected. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：483 / 485

页数：3

共 10 条

[1]

Berger H, 1963, RECL TRAV CHIM PAY B, V82, P773

[2]

CHAI CLL, 2000, IN PRESS REDOX REPOR

[3] EQUILIBRIUM CONSTANTS FOR REACTION OF GLUTATHIONE WITH CYSTINE AND THEIR RELATIVE OXIDATION-REDUCTION POTENTIALS [J].