In vivo UHMWPE biodegradation of retrieved prosthesis

被引：112

作者：

Costa, L

Luda, MP

Trossarelli, L

del Prever, EMB

Crova, M

Gallinaro, P

机构：

[1] Univ Turin, Dipartimento Chim Inorgan Chim Fis & Chim Mat, I-10125 Turin, Italy

[2] Univ Turin, Ctr Traumatol Ortoped, Clin Ortoped 1, I-10126 Turin, Italy

[3] Univ Turin, Ctr Traumatol Ortoped, Clin Ortoped 2, I-10126 Turin, Italy

来源：

BIOMATERIALS | 1998年 / 19卷 / 15期

关键词：

UHMWPE; biodegradation; oxidation; sterilisation; in vivo ageing;

D O I：

10.1016/S0142-9612(98)00013-1

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Sixty-two ultra high molecular weight polyethylene prosthetic components (PEs) (31 tibial plateaux and 31 cups), sterilised by gamma rays or ethylene oxide (EtO), were retrieved after 1-12 years depending on different medical reasons and were studied by FTIR spectroscopy with derivatisation of oxidised species. Esters, acids and hydroperoxides were found under the surface of the EtO sterilised PEs up to 2 mm depth. The behaviour of gamma ray sterilised PEs is more complex due to the oxidation following the sterilisation process. Ester and acid formation might arise from the diffusion of components of synuvial liquid or from the oxidation process, whereas hydroperoxide formation is thought to be due to the oxidation. Abrasion and delamination process is discussed considering the topological distribution of degradation products. (C) 1998 Elsevier Science Ltd. All rights reserved

引用

页码：1371 / 1385

页数：15

共 53 条

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