Metastamirs: a stepping stone towards improved cancer management

被引：153

作者：

White, Nicole M. A. ^{[1
,2
]}

Fatoohi, Eman ^{[1
,2
]}

Metias, Maged ^{[1
,2
]}

Jung, Klaus ^{[3
]}

Stephan, Carsten ^{[4
]}

Yousef, George M. ^{[1
,2
]}

机构：

[1] St Michaels Hosp, Dept Lab Med, Toronto, ON M5B 1W8, Canada

[2] St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada

[3] Univ Hosp Charite, Berlin Inst Urol Res, D-10117 Berlin, Germany

[4] Univ Hosp Charite, Dept Urol, D-10117 Berlin, Germany

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2011年 / 8卷 / 02期

关键词：

TUMOR-SUPPRESSOR GENE; EPITHELIAL-MESENCHYMAL TRANSITION; MICRORNA EXPRESSION PROFILE; LYMPH-NODE METASTASIS; BREAST-CANCER; MIR-200; FAMILY; HEPATOCELLULAR-CARCINOMA; REPRESSORS ZEB1; DOWN-REGULATION; CELL MIGRATION;

D O I：

10.1038/nrclinonc.2010.173

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are non-coding RNAs that regulate protein expression. Aberrant miRNA expression in cancer has been well documented; miRNAs can act as oncogenes or tumor-suppressor genes, depending on the cellular context and target genes that they regulate, and are involved in tumor progression and metastasis. The potential mechanisms by which miRNAs are involved in tumor aggressiveness include migration, invasion, cell proliferation, epithelial-to-mesenchymal transition, angiogenesis and apoptosis. MiRNAs are involved in various cellular pathways and an miRNA can elicit more than one biological effect in a given cell. Existing data show the potential clinical utility of miRNAs as prognostic and predictive markers for aggressive and metastatic cancers. The stability of miRNAs in formalin-fixed, paraffin-embedded tissues and body fluids is advantageous for biomarker discovery and validation. In addition, miRNAs can be extracted from small biopsy specimens, which is a further advantage. Finally, miRNAs are potential therapeutic agents for personalized cancer management.

引用

页码：75 / 84

页数：10

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