Is there a role for CEA in innate immunity in the colon?

被引：54

作者：

Hammarström, S ^{[1
]}

Baranov, V ^{[1
]}

机构：

[1] Umea Univ, Dept Immunol, SE-90185 Umea, Sweden

来源：

TRENDS IN MICROBIOLOGY | 2001年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0966-842X(01)01952-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carcinoembryonic antigen (CEA) is a well known tumor marker associated with the progression of colorectal tumors. The CEA family of glycoproteins has been fully characterized and the function of some of its members is now beginning to be understood. Here, we advance the hypothesis that, rather than functioning in cell adhesion as has been suggested previously CEA plays a role in protecting the colonic mucosa from microbial invasion. This hypothesis is based on new microscopic, molecular, phytogenetic and microbiological evidence.

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页码：119 / 125

页数：7

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