Serum C-Reactive Protein and Risk of Pancreatic Cancer in Two Nested, Case-Control Studies

被引：25

作者：

Douglas, Jason B. ^{[1
]}

Silverman, Debra T. ^{[2
]}

Weinstein, Stephanie J. ^{[1
]}

Graubard, Barry I. ^{[3
]}

Pollak, Michael N. ^{[4
]}

Tao, Yuzhen ^{[4
]}

Virtamo, Jarmo ^{[5
]}

Albanes, Demetrius ^{[1
]}

Stolzenberg-Solomon, Rachael Z. ^{[1
]}

机构：

[1] NCI, Nutr Epidemiol Branch, Dept Hlth & Human Serv, Rockville, MD USA

[2] NCI, Occupat Epidemiol Branch, Dept Hlth & Human Serv, Rockville, MD USA

[3] NCI, Biostat Branch, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, Rockville, MD USA

[4] McGill Univ, Jewish Gen Hosp, Cancer Prevent Program, Montreal, PQ H3T 1E2, Canada

[5] Natl Inst Hlth & Welfare, Dept Chron Dis Prevent, Helsinki, Finland

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2011年 / 20卷 / 02期

基金：

美国国家卫生研究院;

关键词：

DUCTAL ADENOCARCINOMA; COLORECTAL-CANCER; VITAMIN-D; REPRODUCIBILITY; QUESTIONNAIRE; INFLAMMATION; PROSTATE; LUNG; HEAD;

D O I：

10.1158/1055-9965.EPI-10-1024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Many epidemiologic studies have examined the association between C-reactive protein (CRP) and risk of cancer with inconsistent results. Methods: We conducted two nested, case-control studies in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) and Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) to test whether prediagnostic circulating CRP concentrations were associated with pancreatic adenocarcinoma. Between 1985 and 2004, 311 cases occurred in ATBC and between 1994 and 2006, 182 cases occurred in PLCO. Controls (n = 510 in ATBC, n = 374 in PLCO) were alive at the time the case was diagnosed and were matched by age, date of blood draw, sex, and race. We used conditional logistic regression adjusted for smoking to calculate OR and 95% CI for pancreatic cancer. Results: CRP concentrations (ng/mL) tended to be inversely or not associated with pancreatic cancer risk in ATBC, PLCO, and combined analyses [per standardized quintile increase in CRP, continuous OR = 0.94 (95% CI, 0.89-0.99), OR = 0.99 (95% CI, 0.95-1.04), OR = 0.98 (95% CI, 0.95-1.01), respectively]. In combined analyses, we observed a significant interaction (P-interaction = 0.02) such that inverse associations were suggestive in younger (OR = 0.95; 95% CI, 0.90-1.01), but not older, participants. Conclusion: Our results do not support the hypothesis that higher CRP concentrations are associated with incident pancreatic cancer. Impact: Our results highlight the importance of investigating more specific biomarkers for inflammation that may reflect the biological mechanisms underlying pancreatic cancer in prospective cohort studies. Cancer Epidemiol Biomarkers Prev; 20(2); 359-69. (C)2010 AACR.

引用

页码：359 / 369

页数：11