Autophagy and Tubular Cell Death in the Kidney

被引：90

作者：

Havasi, Andrea ^{[1
]}

Dong, Zheng ^{[2
,3
,4
]}

机构：

[1] Boston Univ, Med Ctr, Dept Nephrol, Boston, MA USA

[2] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Hunan, Peoples R China

[3] Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA

[4] Charlie Norwood VA Med Ctr, Augusta, GA USA

来源：

SEMINARS IN NEPHROLOGY | 2016年 / 36卷 / 03期

关键词：

autophagy; apoptosis; renal tubule; cell death; ENDOPLASMIC-RETICULUM STRESS; ISCHEMIA-REPERFUSION INJURY; UNILATERAL URETERAL OBSTRUCTION; THERAPEUTIC TARGET; OXIDATIVE STRESS; CISPLATIN INJURY; EPITHELIAL-CELLS; PROXIMAL TUBULE; EMERGING ROLE; IN-VITRO;

D O I：

10.1016/j.semnephrol.2016.03.005

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Many common renal insults such as ischemia and toxic injury primarily target the tubular epithelial cells, especially the highly metabolically active proximal tubular segment. Tubular epithelial cells are particularly dependent on autophagy to maintain homeostasis and respond to stressors. The pattern of autophagy in the kidney has a unique spatial and chronologic signature. Recent evidence has shown that there is complex cross-talk between autophagy and various cell death pathways. This review specifically discusses the interplay between autophagy and cell death in the renal tubular epithelia. It is imperative to review this topic because recent discoveries have improved our mechanistic understanding of the autophagic process and have highlighted its broad clinical applications, making autophagy a major target for drug development. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：174 / 188

页数：15

共 156 条

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