Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology

被引：426

作者：

Ross, MF

Kelso, GF

Blaikie, FH

James, AM

Cochemé, HM

Filipovska, A

Da Ros, T

Hurd, TR

Smith, RAJ

Murphy, MP

机构：

[1] MRC, Dunn Human Nutr Unit, Cambridge CB2 2XY, England

[2] Univ Otago, Dept Chem, Dunedin, New Zealand

[3] Univ Trieste, Dept Pharmaceut Sci, I-34127 Trieste, Italy

来源：

BIOCHEMISTRY-MOSCOW | 2005年 / 70卷 / 02期

关键词：

lipophilic phosphonium cations; mitochondria; membrane potential; oxidative damage; antioxidants;

D O I：

10.1007/s10541-005-0104-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioenergetics and free radical biology. Here we review why these molecules are useful in mitochondrial research and outline some of the ways in which they are now being utilized.

引用

页码：222 / 230

页数：9

共 68 条

[1] Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant [J].