N-Terminal-proBNP (NT-proBNP) as an indicator of cardiac dysfunction - A study in patients presenting with suspected cardiac disorders

被引：21

作者：

Hess, G ^{[1
]}

Moecks, J ^{[1
]}

Zdunek, D ^{[1
]}

机构：

[1] Roche Diagnost GmbH, D-68305 Mannheim, Germany

来源：

ZEITSCHRIFT FUR KARDIOLOGIE | 2005年 / 94卷 / 04期

关键词：

N-terminal-pro-brain natriuretic peptide; cardiac dysfunction; left ventricular ejection fraction; thyroid dysfunction; renal impairment; creatinine; glomerular filtration rate (GFR);

D O I：

10.1007/s00392-005-0205-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Natriuretic peptides represent a novel diagnostic tool in the assessment of cardiac dysfunction. Methods A total of 473 consecutive referred patients presenting to 18 cardiologists for the assessment of their cardiac state were recruited for the study. Patients received a medical history, a physical examination an electrocardiogram and an echocardiogram where left ventricular ejection fraction was recorded. Results NT-proBNP was found to correlate with left ventricular ejection fraction (LVEF), level of symptoms (NYHA classification), history of angina pectoris (AP) and myocardial infarction (AMI). Atrial fibrillation (AF) and thyroid dysfunction as well as renal impairment were shown to influence NT-proBNP levels. Conclusion The study supports the hypothesis that NT-proBNP determination contributes to the assessment of patients presenting to cardiologists.

引用

页码：247 / 254

页数：10

共 32 条

[1] Tei-Index in coronary artery disease - validation in patients with overall cardiac and isolated diastolic dysfunction [J].