Combinatorial biosynthesis of polyketides and nonribosomal peptides

被引：66

作者：

Staunton, J

Wilkinson, B

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

[2] Univ Cambridge, Cambridge Ctr Mol Recognit, Cambridge CB2 1EW, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(00)00185-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The engineering of polyketide biosynthesis has begun to provide robust targeted libraries for screening against pharmaceutically relevant targets. New technologies that offer methodology for the rapid generation of more structurally diverse libraries have now been demonstrated.

引用

收藏

页码：159 / 164

页数：6

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