Mineralocorticoid receptors: Distribution and activation

被引:163
作者
Funder, JW [1 ]
机构
[1] Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia
关键词
aldosterone; mineralocorticoid receptors; 11 beta hydroxysteroid dehydrogenase; vascular inflammation; reactive oxygen species; NADH; redox state;
D O I
10.1007/s10741-005-2344-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mineralocorticoid receptors (MR) bind both mineralocorticoids and glucocorticoids with high affinity (deoxycorticosterone = corticosterone >= aldosterone = cortisol), and are found in both Na+ transporting epithelia (e.g. kidney, colon) and nonepithelial tissues (e.g. heart, brain). MR evolved before aldosterone synthase, consistent with their acting in nonepithelial tissues as high affinity glucocorticoid receptors, essentially always occupied by normal levels of endogenous glucocorticoids. In epithelial tissues the enzyme 11 beta hydroxysteroid dehydrogenase Type 2 (11 beta HSD2) allows aldosterone to selectively activate MR, by converting cortisol to cortisone and NAD to NADH. 11 beta HSD2 debulks intracellular cortisol by 90%, to levels similar to 10-fold those of aldosterone, so that when the enzyme is operating most epithelial MR are occupied but not activated by cortisol. When intracellular redox state is changed-by inhibition of 11 beta HSD2, generation of reactive oxygen species, or intracellular introduction of oxidised glutathione (GSSG)-cortisol changes from an MR antagonist to an MR agonist. This bivalent activity of cortisol appears to underlie the therapeutic efficacy of MR blockade in heart failure (RALES, EPHESUS) and in essential hypertension, providing a rationale for MR blockade in cardiovascular disease not characterized by elevated aldosterone levels. Its wider (patho)physiologic implications, particularly for neurobiology, remain to be explored.
引用
收藏
页码:15 / 22
页数:8
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