Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate

被引：200

作者：

Heo, MY ^{[1
]}

Sohn, SJ

Au, WW

机构：

[1] Kangwon Natl Univ, Coll Pharm, Chunchon 200, South Korea

[2] Korea Food & Drug Adm, Div Toxicol, Natl Inst Toxicol Res, Seoul 122704, South Korea

[3] Univ Texas, Med Branch, Dept Prevent Med & Community Hlth, Galveston, TX 77555 USA

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2001年 / 488卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

cancer chemopreventive agent; flavonoid; galangin; anti-genotoxicity; enzyme modulation; anti-oxidative activity;

D O I：

10.1016/S1383-5742(01)00054-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Flavonoids are polyphenolic compounds that are present in plants. They have been shown to possess a variety of biological activities at non-toxic concentrations in organisms. Galangin, a member of the flavonol class of flavonoid, is present in high concentrations in medicinal plants (e.g. Alpinia officinarum) and propolis, a natural beehive product. Results from in vitro and in vivo studies indicate that galangin with anti-oxidative and free radical scavenging activities is capable of modulating enzyme activities and suppressing the genotoxicity of chemicals. These activities will be discussed in this review. Based on our review, galangin may be a promising candidate for cancer chemoprevention. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：135 / 150

页数：16

共 134 条

[1] ACTIVITIES OF FLAVONOIDS FOR THE CLEAVAGE OF DNA IN THE PRESENCE OF CU(II) - CORRELATION WITH GENERATION OF ACTIVE OXYGEN SPECIES [J].

AHMAD, MS ;

FAZAL, F ;

RAHMAN, A ;

HADI, SM ;

PARISH, JH .

CARCINOGENESIS, 1992, 13 (04) :605-608

[2]

AKIYAMA T, 1987, J BIOL CHEM, V262, P5592

[3]

[Anonymous], 1991, NIH PUBL

[4] EFFECT OF PLANT FLAVONOIDS ON MICROSOME CATALYZED-REACTIONS OF AFLATOXIN-B1 LEADING TO ACTIVATION AND DNA ADDUCT FORMATION [J].

BHATTACHARYA, RK ;

FIROZI, PF .

CANCER LETTERS, 1988, 39 (01) :85-91

[5] FRUIT, VEGETABLES, AND CANCER PREVENTION - A REVIEW OF THE EPIDEMIOLOGIC EVIDENCE [J].

BLOCK, G ;

PATTERSON, B ;

SUBAR, A .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1992, 18 (01) :1-29

[6]

BORS W, 1990, METHOD ENZYMOL, V186, P343

[7]

Brosen K, 1995, Clin Pharmacokinet, V29 Suppl 1, P20

[8] MUTAGENICITY OF PLANT FLAVONOLS IN THE SALMONELLA-MAMMALIAN MICROSOME TEST - ACTIVATION OF FLAVONOL GLYCOSIDES BY MIXED GLYCOSIDASES FROM RAT CECAL BACTERIA AND OTHER SOURCES [J].

BROWN, JP ;

DIETRICH, PS .

MUTATION RESEARCH, 1979, 66 (03) :223-240

[9]

BUENING MK, 1981, CANCER RES, V41, P67

[10] GENETIC-EFFECTS OF THE FLAVONOLS QUERCETIN, KAEMPFEROL, AND GALANGIN ON CHINESE-HAMSTER OVARY CELLS-INVITRO [J].

CARVER, JH ;

CARRANO, AV ;

MACGREGOR, JT .

MUTATION RESEARCH, 1983, 113 (01) :45-60

← 1 2 3 4 5 6 7 8 9 10 →