Prenylated xanthones with NGF-potentiating activity from Garcinia xanthochymus

被引：36

作者：

Chanmahasathien, W

Li, YS

Satake, M

Oshima, Y

Ruangrungsi, N

Ohizumi, Y ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Pharmaceut Mol Biol, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Tohoku Univ, Grad Sch Life Sci, Bioorgan Chem Lab, Aoba Ku, Sendai, Miyagi 9818555, Japan

[3] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Bangkok 10330, Thailand

来源：

PHYTOCHEMISTRY | 2003年 / 64卷 / 05期

关键词：

Garcinia xanthochymus; Guttiferae; xanthone; NGF-potentiating activity; PC12D cell;

D O I：

10.1016/S0031-9422(03)00431-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two prenylated xanthones, 1,4,5,6-tetrahydroxy-7,8-di(3-methylbut-2-enyl)xanthone (1) and 1,2,6-trihydroxy-5-methoxy-7-(3-methylbut-2-enyl)xanthone (2), were isolated from the wood of Garcinia xanthochymus along with a known xanthone, 12b-hydroxy-des-D-garcigerrin A (3). Their structures were elucidated by spectroscopic analysis. Compound 1 (10 muM), 2 (10-30 muM) and 3 (10 muM) showed a markedly enchancing activity of nerve growth factor (NGF)-mediated neurite outgrowth on PC12D cells. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：981 / 986

页数：6

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