The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

被引：1423

作者：

Plaks, Vicki ^{[1
]}

Kong, Niwen ^{[1
]}

Werb, Zena ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

来源：

CELL STEM CELL | 2015年 / 16卷 / 03期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; MATRIX METALLOPROTEINASES; BONE-MARROW; MICROENVIRONMENTAL REGULATION; METASTATIC COLONIZATION; CHEMOKINE RECEPTORS; INITIATING CELLS; HETEROGENEITY; DIFFERENTIATION;

D O I：

10.1016/j.stem.2015.02.015

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal, clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in niches, which are anatomically distinct regions within the tumor microenvironment. These niches maintain the principle properties of CSCs, preserve their phenotypic plasticity, protect them from the immune system, and facilitate their metastatic potential. In this perspective, we focus on the CSC niche and discuss its contribution to tumor initiation and progression. Since CSCs survive many commonly employed cancer therapies, we examine the prospects of targeting the niche components as preferable therapeutic targets.

引用

页码：225 / 238

页数：14

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