Online reference database of European Y-chromosomal short tandem repeat (STR) haplotypes

被引:178
作者
Roewer, L
Krawczak, M
Willuweit, S
Nagy, M
Alves, C
Amorim, A
Anslinger, K
Augustin, C
Betz, A
Bosch, E
Cagliá, A
Carracedo, A
Corach, D
Dekairelle, AF
Dobosz, T
Dupuy, BM
Füredi, S
Gehrig, C
Gusmao, L
Henke, J
Henke, L
Hidding, M
Hohoff, C
Hoste, B
Jobling, MA
Kärgel, HJ
de Knijff, P
Lessig, R
Liebeherr, E
Lorente, M
Martínez-Jarreta, B
Nievas, P
Nowak, M
Parson, W
Pascali, VL
Penacino, G
Ploski, R
Rolf, B
Sala, A
Schmidt, U
Schmitt, C
Schneider, PM
Szibor, R
Teifel-Greding, J
Kayser, M
机构
[1] Humboldt Univ, Inst Rechtsmed, D-10115 Berlin, Germany
[2] Cardiff Univ, Inst Med Genet, Cardiff C14 4XN, S Glam, Wales
[3] IPATIMUP, P-4200 Oporto, Portugal
[4] Inst Rechtsmed Munchen, D-80337 Munich, Germany
[5] Inst Rechtsmed, D-22529 Hamburg, Germany
[6] Landeskriminalamt Baden Wurttemberg, D-70372 Stuttgart, Germany
[7] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England
[8] Univ Cattolica Sacro Cuore, Inst Med Legale, I-00168 Rome, Italy
[9] Fac Med, Inst Legal Med, Santiago De Compostela 15705, Spain
[10] Univ Buenos Aires, Fac Farm & Bioquim, Serv Huellas Digitales Genet, RA-1113 Buenos Aires, DF, Argentina
[11] Inst Natl Criminalist & Criminol, B-1120 Brussels, Belgium
[12] Med Univ Wroclaw, Inst Forens Med, PL-50368 Wroclaw, Poland
[13] Univ Oslo, Rikshosp, Inst Forens Med, N-0027 Oslo, Norway
[14] Inst Forens Sci, H-1903 Budapest, Hungary
[15] Inst Med Legale Geneve & Lausanne, CH-1211 Geneva 4, Switzerland
[16] Inst Blutgruppenforsch, D-50672 Cologne, Germany
[17] Univ Cologne, Inst Rechtsmed, D-50823 Cologne, Germany
[18] Univ Munster, Inst Rechtsmed, D-48149 Munster, Germany
[19] Landeskriminalamt Sachsen Anhalt, D-39124 Magdeburg, Germany
[20] Leiden Univ, Med Ctr, Forens Lab DNA Res, MGC Dept Human & Clin Genet, NL-2300 RA Leiden, Netherlands
[21] Univ Leipzig, Inst Rechtsmed, D-4103 Leipzig, Germany
[22] Landeskriminalamt Berlin, D-12101 Berlin, Germany
[23] Univ Granada, Fac Med, Dept Legal Med, E-18071 Granada, Spain
[24] Univ Zaragoza, Dept Forens Med, E-50009 Zaragoza, Spain
[25] Med Acad Warsaw, Dept Forens Med, PL-02007 Warsaw, Poland
[26] Univ Innsbruck, Inst Gerichtl Med, A-6020 Innsbruck, Austria
[27] Univ Freiburg Klinikum, Inst Rechtsmed, D-79104 Freiburg, Germany
[28] Univ Magdeburg, Inst Rechtsmed, D-39112 Magdeburg, Germany
[29] Bayer Landeskriminalamt, D-80636 Munich, Germany
[30] Max Planck Inst Evolutionare Anthropol, Abt Evolutionare Genet, D-4103 Leipzig, Germany
基金
英国惠康基金;
关键词
database; Y chromosome; STR; haplotype; forensics;
D O I
10.1016/S0379-0738(00)00478-3
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
The reference database of highly informative Y-chromosomal short tandem repeat (STR haplotypes (YHRD), available online at http://ystr.charite.de, represents the largest collection of male-specific genetic profiles currently available for European populations. By September 2000, YHRD contained 4688 9-locus (so-called "minimal") haplotypes, 40% of which have been extended further to include two additional loci. Establishment of YHRD has been facilitated by the joint efforts of 31 forensic and anthropological institutions. All contributing laboratories have agreed to standardize their Y-STR haplotyping protocols and to participate in a quality assurance exercise prior to the inclusion of any data. In view of its collaborative character, and in order to put YHRD to its intended use, viz, the support of forensic caseworkers in their routine decision-making process, the database has been made publicly available via the Internet in February 2000. Online searches for complete or partial Y-STR haplotypes from evidentiary or non-probative material can be performed on a non-commercial basis, and yield observed haplotype counts as well as extrapolated population frequency estimates. In addition, the YHRD website provides information about the quality control test, genotyping protocols, haplotype formats and informativity, population genetic analysis, literature references, and a list of contact addresses of the contributing laboratories. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:106 / 113
页数:8
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