Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies

被引：16

作者：

Camidge, DR

Randall, KR

Foster, JR

Sadler, CJ

Wright, JA

Soames, AR

Laud, PJ

Smith, PD

Hughes, AM

机构：

[1] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

[2] Western Gen Hosp, Edinburgh Canc Ctr, Edinburgh EH4 2XU, Midlothian, Scotland

[3] Syngenta, CTL, Macclesfield SK10 4TJ, Cheshire, England

来源：

BRITISH JOURNAL OF CANCER | 2005年 / 92卷 / 10期

关键词：

hair; drug development; pharmacodynamic;

D O I：

10.1038/sj.bjc.6602558

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have demonstrated the feasibility of detecting and quantifying six cell-cycle-related nuclear markers (Ki67, pRb, p27, phospho-p27 (phosphorylated p27), phospho-pRb ( phosphorylated pRb), phospho-HH3 (phosphorylated histone H3)) in plucked human scalp and eyebrow hair. Estimates of the proportion of plucked hairs that are lost or damaged during processing plus the intra- and intersubject variability of each nuclear marker with these techniques are provided to inform sizing decisions for intervention studies with drugs potentially impacting on these markers in the future.

引用

页码：1837 / 1841

页数：5

共 8 条

[1] Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition [J].