Simultaneous PML/RARα and AML1/ETO expression with t(15;17) at onset and relapse with only t(8;21) in an acute promyelocytic leukemia patient

被引：11

作者：

Bonomi, R

Giordano, H

Moreno, MD

Bodega, E

Landoni, AI

Gallagher, R

Uriarte, MD

机构：

[1] Asoc Espanola Primera Socorros Mutuos, Montevideo 11300, Uruguay

[2] Serv Hematol Hosp Marciel, Montevideo, Uruguay

[3] Montefiore Med Ctr, Albert Einstein Canc Ctr, Bronx, NY 10467 USA

来源：

CANCER GENETICS AND CYTOGENETICS | 2000年 / 123卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(00)00297-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a patient with acute promyelocytic leukemia with the common translocation (15;17) and PML-RARA alpha fusion gene. In relapse, blasts showed typical FAB M2 morphologic features, and the karyotype was 45,X, -Y,t(8;21). A reexamination of the leukemic cells at diagnosis revealed that an AML1-ETO fusion gene was also present at that time without cytogenetic evidence of t(8;21). In relapse, only t(8;21) was detected. Two different clones were identified by cytogenetic standard techniques. The association of two common translocations supervening in the same time in the same cells could not be established. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：41 / 43

页数：3

共 19 条

[1] ACQUISITION OF ADDITIONAL PRIMARY CHROMOSOME-ABNORMALITIES IN THE COURSE OF KARYOTYPE EVOLUTION IN A CASE OF FAB-M2 ACUTE-LEUKEMIA [J].