A new property of MCM-41:: Drug delivery system

被引：1865

作者：

Vallet-Regi, M ^{[1
]}

Rámila, A ^{[1
]}

del Real, RP ^{[1
]}

Pérez-Pariente, J ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, E-28040 Madrid, Spain

来源：

CHEMISTRY OF MATERIALS | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1021/cm0011559

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new application of MCM-41 mesoporous materials has been developed. Two kinds of surfactants, C16TAB and C12TAB, have been employed to get different pore sizes. The samples were disk-shaped conformed before and after charging with ibuprofen, an antiinflammatory drug. In all the cases the weight percent ratio of drug/MCM-41 was 30%. The drug release plots show a different behavior depending on the method for charging the drug in the material but not on the employed surfactant.

引用

页码：308 / 311

页数：4

共 17 条

[1] ARCOS D, IN PRESS BIOMATERIAL
[2] A NEW FAMILY OF MESOPOROUS MOLECULAR-SIEVES PREPARED WITH LIQUID-CRYSTAL TEMPLATES
BECK, JS
VARTULI, JC
ROTH, WJ
LEONOWICZ, ME
KRESGE, CT
SCHMITT, KD
CHU, CTW
OLSON, DH
SHEPPARD, EW
MCCULLEN, SB
HIGGINS, JB
SCHLENKER, JL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (27) : 10834 - 10843
[3] Functionalized micelle-templated silicas (MTS) and their use as catalysts for fine chemicals
Brunel, D
[J]. MICROPOROUS AND MESOPOROUS MATERIALS, 1999, 27 (2-3) : 329 - 344
[4] Synthesis of MCM-41 with different pore diameters without addition of auxiliary organics
Corma, A
Kan, QB
Navarro, MT
PerezPariente, J
Rey, F
[J]. CHEMISTRY OF MATERIALS, 1997, 9 (10) : 2123 - 2126
[5] del Real RP, 2000, J BIOMED MATER RES, V52, P1
[6] Functionalized monolayers on ordered mesoporous supports
Feng, X
Fryxell, GE
Wang, LQ
Kim, AY
Liu, J
Kemner, KM
[J]. SCIENCE, 1997, 276 (5314) : 923 - 926
[7] Alkaline lyotropic silicate-surfactant liquid crystals
Firouzi, A
Atef, F
Oertli, AG
Stucky, GD
Chmelka, BF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (15) : 3596 - 3610
[8] GALARNEAU A, 1996, MICROPOROUS MESOPORO, V8, P1147
[9] METAMORPHIC MATERIALS - RESTRUCTURING SILICEOUS MESOPOROUS MATERIALS
KHUSHALANI, D
KUPERMAN, A
OZIN, GA
TANAKA, K
GARCES, J
OLKEN, MM
COOMBS, N
[J]. ADVANCED MATERIALS, 1995, 7 (10) : 842 - &
[10] SOLUTIONS ABLE TO REPRODUCE INVIVO SURFACE-STRUCTURE CHANGES IN BIOACTIVE GLASS-CERAMIC A-W3
KOKUBO, T
KUSHITANI, H
SAKKA, S
KITSUGI, T
YAMAMURO, T
[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1990, 24 (06): : 721 - 734

← 1 2 →