APC signaling: tickling PAR1 for barrier protection?

被引：10

作者：

Camerer, E ^{[1
]}

Coughlin, SR ^{[1
]}

机构：

[1] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

BLOOD | 2005年 / 105卷 / 08期

关键词：

D O I：

10.1182/blood-2005-01-0334

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

APC can trigger activation of the thrombin receptor PAR1 on endothelial cells. Is this important for the pharmacologic actions of APC? Endothelial barrier protection by PAR1 transactivation of SIP1 raises this possibility.

引用

页码：3004 / 3005

页数：2

共 6 条

[1] Efficacy and safety of recombinant human activated protein C for severe sepsis. [J].

Bernard, GR ;

Vincent, JL ;

Laterre, P ;

LaRosa, SP ;

Dhainaut, JF ;

Lopez-Rodriguez, A ;

Steingrub, JS ;

Garber, GE ;

Helterbrand, JD ;

Ely, EW ;

Fisher, CJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) :699-709

[2] Interactions between the innate immune and blood systems coagulation [J].

Esmon, CT .

TRENDS IN IMMUNOLOGY, 2004, 25 (10) :536-542

[3] Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement [J].

Garcia, JGN ;

Liu, F ;

Verin, AD ;

Birukova, A ;

Dechert, MA ;

Gerthoffer, WT ;

Bamburg, JR ;

English, D .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (05) :689-701

[4]

LUDEMAN MJ, 2005, J BIOL CHEM

[5] Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia [J].

Pawlinski, R ;

Pedersen, B ;

Schabbauer, G ;

Tencati, M ;

Holscher, T ;

Boisvert, W ;

Andrade-Gordon, P ;

Frank, RD ;

Mackman, N .

BLOOD, 2004, 103 (04) :1342-1347

[6] Activation of endothelial cell protease activated receptor 1 by the protein C pathway [J].

Riewald, M ;

Petrovan, RJ ;

Donner, A ;

Mueller, BM ;

Ruf, W .

SCIENCE, 2002, 296 (5574) :1880-1882

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