Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia

被引：11

作者：

de Vries, Andrica C. H. ^{[1
]}

Stam, Ronald W. ^{[1
]}

Kratz, Christian P. ^{[2
]}

Zenker, Martin ^{[3
]}

Niemeyer, Charlotte M. ^{[2
]}

van den Heuvel-Eibrink, Marry M. ^{[1
,4
]}

机构：

[1] Erasmus MC, Sophia Childrens Hosp, Dept Pediat Oncol Hematol, Rotterdam, Netherlands

[2] Univ Freiburg, Dept Pediat & Adolescent Med, Div Pediat Hematol & Oncol, Freiburg, Germany

[3] Univ Erlangen Nurnberg, Inst Human Genet, Erlangen, Germany

[4] Dutch Childhood Oncol Grp, The Hague, Netherlands

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 11期

关键词：

BRAF; juvenile myelomonocytic leukemia;

D O I：

10.3324/haematol.11493

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERKsignaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.

引用

页码：1574 / 1575

页数：2

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