Paclitaxel-induced cell-mediated hypersensitivity pneumonitis - Diagnosis using leukocyte migration test, bronchoalveolar lavage and transbronchial lung biopsy

被引：48

作者：

Fujimori, K ^{[1
]}

Yokoyama, A ^{[1
]}

Kurita, Y ^{[1
]}

Uno, K ^{[1
]}

Saijo, N ^{[1
]}

机构：

[1] Niigata Canc Ctr Hosp, Dept Internal Med, Niigata, Japan

来源：

ONCOLOGY | 1998年 / 55卷 / 04期

关键词：

delayed type hypersensitivity; drug-induced pneumonitis; hypersensitivity pneumonitis; leukocyte migration test; paclitaxel;

D O I：

10.1159/000011873

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 73-year-old man with mild inactive interstitial pneumonitis and non-small cell bronchogenic carcinoma developed a cell-mediated hypersensitivity pneumonitis within 15 days following a second exposure to paclitaxel, Histological features of transbronchial lung biopsy were consistent with interstitial pneumonitis. Bronchoalveolar lavage showed increased lymphocytes and eosinophils, and decreased helper/suppressor T lymphocyte ratio, Leukocyte migration inhibitory test was positive for paclitaxel. These results support the possibility that paclitaxel-induced pneumonitis is due to delayed type hypersensitivity; they also support the hypothesis of a central role of T lymphocytes in drug-induced pneumonitis.

引用

页码：340 / 344

页数：5

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