Chiral analysis of basic drugs by oligosaccharide-mediated capillary electrophoresis

被引：40

作者：

DHulst, A ^{[1
]}

Verbeke, N ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,B-3000 LOUVAIN,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 735卷 / 1-2期

关键词：

buffer composition; enantiomer separation; drugs; basic; maltodextrin;

D O I：

10.1016/0021-9673(95)01356-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A low-dextrose-equivalent maltodextrin was investigated for application as an enantioselective electrolyte modifier in direct chiral capillary electrophoresis. A wide range of basic racemic drug substances belonging to different pharmacological groups (antiarrhythmic, anticholinergic, antifungal, antihistaminic, antidepressant and antipsychotic drugs) could be baseline resolved. The background electolyte cation and the anion were found to affect the enantioselectivity significantly. In addition, a definite effect of background electrolyte anion chirality was observed. The use of a single enantiomer background electrolyte could either enhance or completely abolish maltodextrin-mediated chiral separation and in one particular case (aminopromazine) was even sufficient to generate complete enantiomeric resolution.

引用

页码：283 / 293

页数：11

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