Supramolecular hydrogels based on short peptides linked with conformational switch

被引：98

作者：

Huang, Yucheng ^{[1
]}

Qiu, Zhenjun ^{[1
]}

Xu, Yanmei ^{[1
]}

Shi, Junfeng ^{[2
]}

Lin, Hongkun ^{[1
]}

Zhang, Yan ^{[1
]}

机构：

[1] Nanjing Univ, Minist Educ China, Key Lab Analyt Chem Life Sci, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China

[2] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 07期

基金：

美国国家科学基金会;

关键词：

SOL/SOL-GEL TRANSITION; MASS ORGANIC GELATORS; IN-VIVO; LIGHT; ORGANOGELS; CELLS; DERIVATIVES; TRIPEPTIDE; MOLECULES; RECEPTOR;

D O I：

10.1039/c0ob01057j

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Short peptides appropriately linked with an azobenzene conformational switch were found to be motif and pH dependant supramolecular hydrogelators. The hydrogelation properties of the short peptides linked with the conformational switch were studied in detail with respect to dependence on amino acid residue, pH and salt effect. The presence of amino acids with aromatic side chains such as Phe and Tyr was found to be favorable for the short peptides to gel water at an appropriate pH range. Cationic amino acid residues such as Arg and Lys in the short peptides were found to be unfavorable for hydrogelation. pH and salt effect were also found to be important factors for the hydrogelation properties of the short peptides. A series of short peptides with bioactive sequences were linked with the conformational switch and their hydrogelation properties were investigated. Photoresponsive supramolecular hydrogels were realized based on the E-/Z-transition of the conformational switch upon light irradiation. Proper combination of amino acid residues in the short peptides resulted in smart supramolecular hydrogels with responses to multiple stimuli.

引用

页码：2149 / 2155

页数：7

共 59 条

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Casein-Derived Tripeptide, Val-Pro-Pro (VPP), Modulates Monocyte Adhesion to Vascular Endothelium [J].