Autophagosomes and human diseases

被引：62

作者：

Beau, Isabelle ^{[1
]}

Mehrpour, Maryam ^{[1
]}

Codogno, Patrice ^{[1
]}

机构：

[1] Univ Paris 11, Fac Pharm, INSERM U984, F-92296 Chatenay Malabry, France

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2011年 / 43卷 / 04期

关键词：

Macroautophagy; Autophagosome; Cell survival; Lysosome; Protein degradation; ENDOPLASMIC-RETICULUM; MACROAUTOPHAGY; BIOGENESIS; STARVATION; STRESS;

D O I：

10.1016/j.biocel.2011.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The autophagosome is a double-membrane bound compartment that initiates macroautophagy, a degradative pathway for cytoplasmic material terminating in the lysosomal compartment. The discovery of ATG genes involved in the formation of autophagosomes has greatly increased our understanding of the molecular basis of macroautophagy, and its role in cell function. Macroautophagy plays a pivotal role in cell fitness by removing obsolete organelles and protein aggregates. Its stimulation is an adaptive response to stressful situations, such as nutrient deprivation, intended to maintain a level of ATP compatible with cell survival. Macroautophagy is central for organ homeostasis, embryonic development, and longevity. Malfunctioning autophagy is observed in many human diseases including cancer, neurodegenerative diseases, cardiac and muscular diseases, infectious and inflammatory diseases, diabetes, and obesity. Discovering potential drug therapies that can be used to modulate macroautophagy is a major challenge, and likely to enhance the therapeutic arsenal against many human diseases. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：460 / 464

页数：5

共 30 条

[1] Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum [J].

Axe, Elizabeth L. ;

Walker, Simon A. ;

Manifava, Maria ;

Chandra, Priya ;

Roderick, H. Llewelyn ;

Habermann, Anja ;

Griffiths, Gareth ;

Ktistakis, Nicholas T. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (04) :685-701

[2] Network organization of the human autophagy system [J].

Behrends, Christian ;

Sowa, Mathew E. ;

Gygi, Steven P. ;

Harper, J. Wade .

NATURE, 2010, 466 (7302) :68-U84

[3] Inhibition of macroautophagy triggers apoptosis [J].

Boya, P ;

González-Polo, RA ;

Casares, N ;

Perfettini, JL ;

Dessen, P ;

Larochette, N ;

Métivier, D ;

Meley, D ;

Souquere, S ;

Yoshimori, T ;

Pierron, G ;

Codogno, P ;

Kroemer, G .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (03) :1025-1040

[4] Toll-like receptors control autophagy [J].

Delgado, Monica A. ;

Elmaoued, Rasha A. ;

Davis, Alexander S. ;

Kyei, George ;

Deretic, Vojo .

EMBO JOURNAL, 2008, 27 (07) :1110-1121

[5] Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet [J].

Ebato, Chie ;

Uchida, Toyoyoshi ;

Arakawa, Masayuki ;

Komatsu, Masaaki ;

Ueno, Takashi ;

Komiya, Koji ;

Azuma, Kosuke ;

Hirose, Takahisa ;

Tanaka, Keiji ;

Kominami, Eiki ;

Kawamori, Ryuzo ;

Fujitani, Yoshio ;

Watada, Hirotaka .

CELL METABOLISM, 2008, 8 (04) :325-332

[6] Induction of autophagy by spermidine promotes longevity [J].

Eisenberg, Tobias ;

Knauer, Heide ;

Schauer, Alexandra ;

Buettner, Sabrina ;

Ruckenstuhl, Christoph ;

Carmona-Gutierrez, Didac ;

Ring, Julia ;

Schroeder, Sabrina ;

Magnes, Christoph ;

Antonacci, Lucia ;

Fussi, Heike ;

Deszcz, Luiza ;

Hartl, Regina ;

Schraml, Elisabeth ;

Criollo, Alfredo ;

Megalou, Evgenia ;

Weiskopf, Daniela ;

Laun, Peter ;

Heeren, Gino ;

Breitenbach, Michael ;

Grubeck-Loebenstein, Beatrix ;

Herker, Eva ;

Fahrenkrog, Birthe ;

Froehlich, Kai-Uwe ;

Sinner, Frank ;

Tavernarakis, Nektarios ;

Minois, Nadege ;

Kroemer, Guido ;

Madeo, Frank .

NATURE CELL BIOLOGY, 2009, 11 (11) :1305-U102

[7] Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation [J].

Hailey, Dale W. ;

Rambold, Angelika S. ;

Satpute-Krishnan, Prasanna ;

Mitra, Kasturi ;

Sougrat, Rachid ;

Kim, Peter K. ;

Lippincott-Schwartz, Jennifer .

CELL, 2010, 141 (04) :656-667

[8] A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation [J].

Hayashi-Nishino, Mitsuko ;

Fujita, Naonobu ;

Noda, Takeshi ;

Yamaguchi, Akihito ;

Yoshimori, Tamotsu ;

Yamamoto, Akitsugu .

NATURE CELL BIOLOGY, 2009, 11 (12) :1433-U102

[9] An Autophagy-Enhancing Drug Promotes Degradation of Mutant α1-Antitrypsin Z and Reduces Hepatic Fibrosis [J].

Hidvegi, Tunda ;

Ewing, Michael ;

Hale, Pamela ;

Dippold, Christine ;

Beckett, Caroline ;

Kemp, Carolyn ;

Maurice, Nicholas ;

Mukherjee, Amitava ;

Goldbach, Christina ;

Watkins, Simon ;

Michalopoulos, George ;

Perlmutter, David H. .

SCIENCE, 2010, 329 (5988) :229-232

[10] Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy [J].

Hosokawa, Nao ;

Hara, Taichi ;

Kaizuka, Takeshi ;

Kishi, Chieko ;

Takamura, Akito ;

Miura, Yutaka ;

Iemura, Shun-ichiro ;

Natsume, Tohru ;

Takehana, Kenji ;

Yamada, Naoyuki ;

Guan, Jun-Lin ;

Oshiro, Noriko ;

Mizushima, Noboru .

MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (07) :1981-1991

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