Induction of inflammatory gene expression by THP-1 macrophages cultured in normocholesterolaemic hypertensive sera and modulatory effects of green tea polyphenols

被引：14

作者：

Mahajan, N. ^{[1
]}

Dhawan, V. ^{[1
]}

Sharma, G. ^{[1
]}

Jain, S. ^{[2
]}

Kaul, D. ^{[1
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Expt Med & Biotechnol, Chandigarh 160012, India

[2] Postgrad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India

来源：

JOURNAL OF HUMAN HYPERTENSION | 2008年 / 22卷 / 02期

基金：

英国科研创新办公室;

关键词：

D O I：

10.1038/sj.jhh.1002277

中图分类号：

R6 [外科学];

学科分类号：

1002 [临床医学]; 100210 [外科学];

摘要：

Hypertension is a disorder controlled by multiple genes and inflammation and vascular remodelling of arteries have been implicated in pathogenesis of this disease. Green tea polyphenols (GrTPs) are rich in antioxidants and are known to inhibit inflammatory responses. A significant time-dependent increase in mRNA expression of both IL-6 and MMP-9 were observed in THP-1 macrophages when cultured in normocholesterolaemic hypertensive sera (P < 0.05).

引用

页码：141 / 143

页数：3

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