The pathophysiology of brain edema in acute liver failure

被引：56

作者：

Blei, AT ^{[1
]}

机构：

[1] Lakeside VA Med Ctr, Dept Med, Div Hepatol, Chicago, IL 60611 USA

来源：

NEUROCHEMISTRY INTERNATIONAL | 2005年 / 47卷 / 1-2期

关键词：

brain edema; acute liver failure; intracranial hypertension;

D O I：

10.1016/j.neuint.2005.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain edema leading to intracranial hypertension is a cause of death in acute liver failure (ALF). The pathogenesis of this unique complication has been investigated in man, in experimental models and in isolated cell systems. From this experience, an integrated view has emerged, pointing at several mechanisms that contribute to cerebral swelling; an osmotic derangement in astrocytes, changes in cellular metabolism as well as alterations of cerebral blood flow. The ability of mild hypothermia to counteract each of these changes in experimental systems has supported the organization of a clinical trial of mild cooling in this disease. Such an advance can be viewed as the clinical translation of 20 years of research in this area. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：71 / 77

页数：7

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