The role of deubiquitinating enzymes in chromatin regulation

被引：58

作者：

Atanassov, Boyko S.

Koutelou, Evangelia

Dent, Sharon Y. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Mol Carcinogenesis, Div Sci Pk Res, Smithville, TX 78957 USA

来源：

FEBS LETTERS | 2011年 / 585卷 / 13期

关键词：

Cell cycle; Chromatin; Deubiquitination; Histones; Transcriptional regulation; HISTONE H2B UBIQUITYLATION; TUMOR-SUPPRESSOR PROTEIN; RNA-POLYMERASE-II; STEM-CELL MARKER; BRCA1-ASSOCIATED PROTEIN-1; LINK UBIQUITYLATION; GENE-EXPRESSION; H3; METHYLATION; UBIQUITINATION; COMPLEX;

D O I：

10.1016/j.febslet.2010.10.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Post-translational modifications of the histones are centrally involved in the regulation of all DNA-templated processes, including gene transcription, DNA replication, recombination, and repair. These modifications are often dynamic, and their removal is just as important as their addition in proper regulation of cellular functions. Although histone acetylation/deacetylation and histone methylation/demethylation are highly studied, the functions and regulation of histone ubiquitination and deubiquitination are less well understood. This review highlights our current understanding of how histone ubiquitination impacts gene transcription, DNA repair, and cell cycle progression, and stresses the importance of deubiquitinases to normal cellular functions as well as to disease states such as cancer. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：2016 / 2023

页数：8

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